nSides: An interactive drug–side effect gateway

TitlenSides: An interactive drug–side effect gateway
Publication TypeConference Paper
Year of Publication2017
AuthorsVanguri R, Romano J, Lorberbaum T, Youn C, Nwankwo V, Tatonetti N
Date Published10/2017
PublisherGateways 2017 Conference
Conference Location Ann Arbor, Michigan

Adverse drug events are a leading cause of morbidity and mortality around the world. Regulatory agencies, such as the Food and Drug Administration (FDA), maintain large collections of adverse event reports. These spontaneous reporting systems provide an opportunity to retrospectively study drug effects from patient population data. To make our results more accessible, we present a gateway to a new database of drug interactions (nSides) developed using the FDA Adverse Event Reporting System. Side effects for a variety of drugs and drug interactions are presented. Additionally, for high order drug combinations, with the support of the Science Gateway Community Institute's Extended Developer Support, we develop a novel system to request new models to be generated using the Open Science Grid on-demand.