Cyberinfrastructure for Comparative Effectiveness Research (CYCORE)

In this project, UCSD researchers from Calit2 CWPHS and the SDSC ACID group are working with cancer researchers at the M.D. Anderson Cancer Center in Houston, Texas to develop a comprehensive, state-of-the-art cyberplatform to enable large-scale and robust comparative effectiveness research across the neoplastic continuum, i.e., from cancer prevention, to cancer treatment, and ultimately, to cancer control and survivorship care.

This is a 2-year (2009–2011) Grand Opportunity ARRA grant funded by the National Cancer Institute to design and validate, within a community of cancer investigators and patients, a prototype cyberinfrastructure (CI) that supports the acquisition, storage, quality assurance, visualization, analysis, and sharing of clinical, genetic, physiologic, and behavioral data for cancer-related trials. One of the key areas to be addressed in CYCORE is how to collect behavioral and social data relevant to cancer outcomes from free-living individuals in their homes and communities. Thus, a major component of this project is exploring the use of wearable sensors linked to home-health communication hubs so that information can be gathered and integrated into comparative effectiveness research studies alongside clinical and other data.

The role of ACID researchers in this project is to investigate data interoperability issues among the various data systems, including use of knowledge structures such as controlled vocabularies and ontologies, as well as interoperability with CaBIG services.

Principal Investigators: 

M.D. Anderson Cancer Center: Susan Peterson, PhD, Wendy Demark-Wahnefried, PhD, Karen Basen-Engquist, PhD, and Alex Prokhorov, MD UCSD/Calit2: Kevin Patrick, MD, MS UCSD/Calit2: Ingolf Krueger, PhD, Chaitan Baru, PhD, Fred Raab, Doug Palmer, PhD, Phil Rios

Funding Source: 

NIH National Cancer Institute

Science: